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"Everyone is going to get to the point where they increase their dosage and it will not work as well as it did before," he says. "The goal is to use the dose that gives the most minimal noticeable effect," says Sulak. "If I see someone with multiple sclerosis who is in the middle of a flare-up and having a really hard time, she may need a higher dose to get the symptoms under control," he says. Sulak has also noticed that the use of lower doses can actually lead to increased sensitivity to cannabis over time, thus underscoring the importance of staying at low levels for the first few days of microdosing. This can be affected by individual differences in liver metabolism,
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telegram4israel.net) Sulak notes that tests on animals suggest that low-level doses of THC can result in an upregulation of the endocannabinoid system (for endocannabinoid production as well as expression of its receptors). For those using cannabis regularly, Sulak recommends an initial 48-hour period of abstinence, which he believes is enough time to reset the endocannabinoid system. Ross generally recommends that first time microdosers should start off at 2.5 milligrams, maintain that level for approximately three days, and increase if necessary.